LIXTE Biotechnology Holdings, Inc. Quarterly report pursuant to Section 13 or 15(d)

Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies (Details Narrative)

Commitments and Contingencies (Details Narrative) - USD ($)											2 Months Ended	3 Months Ended		5 Months Ended	6 Months Ended
	Jun. 22, 2023	Apr. 17, 2023	Nov. 06, 2022	Oct. 01, 2022	Jun. 10, 2022	Apr. 09, 2021	Feb. 05, 2021	Aug. 20, 2018	Sep. 14, 2015	Dec. 24, 2013	Aug. 31, 2020	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2023	Jun. 30, 2022
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Contractual commitment												$ 6,389,000		$ 6,389,000	$ 6,389,000
Research and development costs												427,457	$ 164,810		616,542	$ 623,261
Aggregate commitments expected												100,000		100,000	100,000
Forman [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Compensation			$ 200,000
Paid office rent				$ 1,500								1,530			4,113
Officer [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Compensation			$ 800,000
City of Hope [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Aggregate commitments expected												69,681		69,681	69,681
Moffitt Cancer Center and Research Institute Hospital Inc [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Research and development costs															147,572
GEIS [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Amount related to milestone payment															684,652
NDA Consulting Corp [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Consulting and advisory fee										$ 4,000		4,000	4,000		8,000	8,000
Clinical Trial Research Agreement [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Advance amount related to milestone payment															6,000	6,073
Research and development costs															12,000	9,405
Clinical Trial Research Agreements [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Research and development costs														143,074
Other Clinical Agreements [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Research and development costs															1,144,000
Collaboration Agreement [Member] \| GEIS [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Research and development costs												268,829	0		268,829	0
Aggregate commitments expected												3,536,000		3,536,000	3,536,000
Collaboration Agreement [Member] \| Bio Pharma Works LLC [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Consulting and advisory fee									$ 10,000
Reimbursed expense												30,000	30,000		60,000	60,000
Clinical Research Support Agreement [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Aggregate commitments expected												800,000		800,000	800,000
Clinical Research Support Agreement [Member] \| City of Hope [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Research and development costs															69,001	0
Aggregate commitments expected												2,433,000		2,433,000	2,433,000
Total costs												447,512		447,512	447,512
Work Order Agreement [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Aggregate commitments expected												153,000		153,000	153,000
Total costs												6,250		6,250	6,250
Work Order Agreement [Member] \| City of Hope [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Advance amount related to milestone payment												5,687	11,235		11,240	15,735
Research and development costs							$ 335,000
Aggregate commitments expected												267,000		267,000	267,000
Work Order Agreement [Member] \| Theradex Systems, Inc. [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Research and development costs													4,558		6,250	7,839
Work cost	$ 153,000
Percentage of payment through services	7200.00%
Percentage of payment through software	2800.00%
Work Order Agreement [Member] \| Moffitt Cancer Center and Research Institute Hospital Inc [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Research and development costs												10,997			20,284
Exclusive License Agreement [Member] \| First Four Years [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Minimum payments for royalties															50,000
Exclusive License Agreement [Member] \| Five Years And Thereafter [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Minimum payments for royalties															100,000
Exclusive License Agreement [Member] \| Moffitt Cancer Center and Research Institute Hospital Inc [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Non refundable license issue fee								$ 25,000
Maintenance fee								25,000
Payment on non refundable milestone								$ 1,897,000
Operating costs and expenses												6,233	6,233		12,398	12,398
Employment Agreement [Member] \| Executive Officers [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Salary and compensation											$ 640,000
Agreement term description											one-year periods
Employment Agreement [Member] \| Dr.James [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Annual compensation						$ 775,000
Development Collaboration Agreement [Member] \| Netherlands Cancer Institute [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Advance amount related to milestone payment												53,178	48,886		105,381	103,116
Research and development costs															364,788
Aggregate commitments expected												53,000		$ 53,000	53,000
MRI Global [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Advance amount related to milestone payment												$ 4,010	$ 19,597		7,183	$ 20,353
Research and development costs															$ 225,924
Contract price		$ 326,274			$ 273,980