<?xml version="1.0" encoding="UTF-8" ?><!-- Generated on Mon, 13 Apr 2026 11:30:37 -0400--><rss version="2.0">
    <channel>
        <title>LIXTE Biotechnology Holdings, Inc. (LIXT) SEC Filings</title>
        <link>https://ir.lixte.com/sec-filings/all-sec-filings/rss</link>
        <description>LIXTE Biotechnology Holdings, Inc. (LIXT) - All SEC Filings</description>
        <language>en-us</language>
                                            <image>
                <url>https://d1io3yog0oux5.cloudfront.net/_a6aa5996494565f9a411e7ae6a5cce0b/lixte/files/theme/images/logo-sm.png</url>
                <title>LIXTE Biotechnology Holdings, Inc. Logo</title>
                <link></link>
            </image>
                <generator>Equisolve Investor Relations Suite</generator>
        
                            <item>
                <title><![CDATA[10-K - Annual report [Section 13 and 15(d), not S-K Item 405]]]></title>
                <description><![CDATA[6 Related Documents: 10-K, EX-23.1, EX-31.1, EX-31.2, EX-32.1, EX-32.2]]></description>
                <link>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-26-014052/0001493152-26-014052.pdf</link>
                <pubDate>Tue, 31 Mar 26 15:12:57 -0400</pubDate>
                <guid>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-26-014052/0001493152-26-014052.pdf</guid>
                                                                            </item>
                    <item>
                <title><![CDATA[8-K - Current report]]></title>
                <description><![CDATA[2 Related Documents: 8-K, EX-10.1]]></description>
                <link>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-26-011829/0001493152-26-011829.pdf</link>
                <pubDate>Fri, 20 Mar 26 16:05:55 -0400</pubDate>
                <guid>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-26-011829/0001493152-26-011829.pdf</guid>
                                                                            </item>
                    <item>
                <title><![CDATA[8-K - Current report]]></title>
                <description><![CDATA[2 Related Documents: 8-K, EX-10.1]]></description>
                <link>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-26-009526/0001493152-26-009526.pdf</link>
                <pubDate>Tue, 10 Mar 26 16:01:10 -0400</pubDate>
                <guid>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-26-009526/0001493152-26-009526.pdf</guid>
                                                                            </item>
                    <item>
                <title><![CDATA[8-K - Current report]]></title>
                <description><![CDATA[4 Related Documents: 8-K, EX-10.1, EX-10.2, EX-99.1]]></description>
                <link>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-26-007268/0001493152-26-007268.pdf</link>
                <pubDate>Wed, 18 Feb 26 08:32:13 -0500</pubDate>
                <guid>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-26-007268/0001493152-26-007268.pdf</guid>
                                                                            </item>
                    <item>
                <title><![CDATA[8-K - Current report]]></title>
                <description><![CDATA[2 Related Documents: 8-K, EX-10.1]]></description>
                <link>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-25-029778/0001493152-25-029778.pdf</link>
                <pubDate>Wed, 31 Dec 25 16:01:12 -0500</pubDate>
                <guid>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-25-029778/0001493152-25-029778.pdf</guid>
                                                                            </item>
                    <item>
                <title><![CDATA[4 - Statement of changes in beneficial ownership of securities]]></title>
                <description><![CDATA[4]]></description>
                <link>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-25-029459/0001493152-25-029459.pdf</link>
                <pubDate>Mon, 29 Dec 25 19:19:34 -0500</pubDate>
                <guid>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-25-029459/0001493152-25-029459.pdf</guid>
                                                                            </item>
                    <item>
                <title><![CDATA[4 - Statement of changes in beneficial ownership of securities]]></title>
                <description><![CDATA[4]]></description>
                <link>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-25-029460/0001493152-25-029460.pdf</link>
                <pubDate>Mon, 29 Dec 25 19:19:31 -0500</pubDate>
                <guid>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-25-029460/0001493152-25-029460.pdf</guid>
                                                                            </item>
                    <item>
                <title><![CDATA[8-K - Current report]]></title>
                <description><![CDATA[4 Related Documents: 8-K, EX-10.1, EX-10.2, EX-99.1]]></description>
                <link>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-25-028999/0001493152-25-028999.pdf</link>
                <pubDate>Tue, 23 Dec 25 16:01:28 -0500</pubDate>
                <guid>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-25-028999/0001493152-25-028999.pdf</guid>
                                                                            </item>
                    <item>
                <title><![CDATA[8-K - Current report]]></title>
                <description><![CDATA[8 Related Documents: 8-K, EX-4.1, EX-4.2, EX-5.1, EX-10.1, EX-10.2, EX-10.3, EX-99.1]]></description>
                <link>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-25-028850/0001493152-25-028850.pdf</link>
                <pubDate>Mon, 22 Dec 25 17:29:52 -0500</pubDate>
                <guid>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-25-028850/0001493152-25-028850.pdf</guid>
                                                                            </item>
                    <item>
                <title><![CDATA[424B5 - Prospectus [Rule 424(b)(5)]]]></title>
                <description><![CDATA[424B5]]></description>
                <link>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-25-028431/0001493152-25-028431.pdf</link>
                <pubDate>Fri, 19 Dec 25 06:15:52 -0500</pubDate>
                <guid>https://ir.lixte.com/sec-filings/all-sec-filings/content/0001493152-25-028431/0001493152-25-028431.pdf</guid>
                                                                            </item>
            </channel>
</rss>