Annual report pursuant to Section 13 and 15(d)

Cover

v3.22.1
Cover - USD ($)
12 Months Ended
Dec. 31, 2021
Mar. 11, 2022
Jun. 30, 2021
Document Type 10-K    
Amendment Flag false    
Document Annual Report true    
Document Transition Report false    
Document Period End Date Dec. 31, 2021    
Document Fiscal Period Focus FY    
Document Fiscal Year Focus 2021    
Current Fiscal Year End Date --12-31    
Entity File Number 000-51476    
Entity Registrant Name LIXTE BIOTECHNOLOGY HOLDINGS, INC.    
Entity Central Index Key 0001335105    
Entity Tax Identification Number 20-2903526    
Entity Incorporation, State or Country Code DE    
Entity Address, Address Line One 680 East Colorado Boulevard    
Entity Address, Address Line Two Suite 180    
Entity Address, City or Town Pasadena    
Entity Address, State or Province CA    
Entity Address, Postal Zip Code 91101    
City Area Code 631    
Local Phone Number 830-7092    
Entity Well-known Seasoned Issuer No    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Filer Category Non-accelerated Filer    
Entity Small Business true    
Entity Emerging Growth Company false    
Entity Shell Company false    
Entity Public Float     $ 30,550,000
Entity Common Stock, Shares Outstanding   13,746,593  
ICFR Auditor Attestation Flag false    
Auditor Firm ID 572    
Auditor Name Weinberg & Company, P.A    
Auditor Location Los Angeles, California    
Common Stock [Member]      
Title of 12(b) Security Common Stock, par value $0.0001 per share    
Trading Symbol LIXT    
Security Exchange Name NASDAQ    
Warrant [Member]      
Title of 12(b) Security Warrants to Purchase Common Stock, par value $0.0001 per share    
Trading Symbol LIXTW    
Security Exchange Name NASDAQ