Lixte Biotechnology's Protein Phosphatase 2A Inhibitor, LB-100, Reported to be a Potentiator of Immunotherapy in an Animal Model

EAST SETAUKET, NY -- (Marketwired) -- 04/17/17 -- Lixte Biotechnology Holdings, Inc. (OTCQB: LIXT) presented a late-breaking abstract entitled "Protein phosphatase 2A inhibition with a novel small molecule inhibitor, LB-100, achieves durable immune-mediated antitumor activity when combined with PD-1 blockade in a preclinical model" as a poster (abstract number LB-193) at the American Association for Cancer Research (AACR) Annual Meeting 2017 in Washington, DC on April 4th. This research was done in collaboration with scientists at the National Institute of Neurological Disorders and Stroke (NINDS), NIH.

Dr. John S. Kovach, CEO of Lixte, said, "The study shows that in an animal model Lixte's lead clinical compound, LB-100 has synergistic potential in conjunction with immune checkpoint blockade supporting investigation of its ability to enhance immunotherapy in the clinic. LB-100, a novel, first-in-class, small molecule inhibitor of protein phosphatase 2A (PP2A), recently completed a Phase 1 trial in patients with advanced cancer (Chung 2016). In that trial, LB-100, was well tolerated at doses associated with stabilization of progressive solid tumors in 10 of 21 patients with receiving 2 or more courses of treatment. One patient with previously refractory pancreatic cancer had a partial regression for 11 months."

Dr. Kovach continued, "Based on a number of published preclinical studies, we had expected that LB-100 will be therapeutically useful primarily as a potentiator of cytotoxic anti-cancer drugs and x-ray. The present study, however, raises the possibility that, in addition, LB-100 may have a role in enhancing the efficacy of so-called 'immune checkpoint blockers' -- agents that allow patients' own immune system to attack their own cancers."

About Lixte Biotechnology Holdings, Inc.
Lixte is a drug discovery company that uses biomarker technology to identify enzyme targets associated with serious common diseases and then design novel compounds to attack those targets. Lixte's product pipeline encompasses two major categories of compounds at various stages of pre-clinical and clinical development that the Company believes have broad therapeutic potential not only for cancer but also for other debilitating and life-threatening diseases.

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Source: Lixte Biotechnology Holdings, Inc.