LB-100 and LB-102, Lixte Biotechnology’s Protein Phosphatase 2A Inhibitors, Sensitize BCR-ABL Leukemia Stem Cells to Targeted Therapy with Tyrosine Kinase Inhibitors

EAST SETAUKET, NY, Feb. 09, 2018 (GLOBE NEWSWIRE) -- Lixte Biotechnology Holdings, Inc. (OTCQB: LIXT) noted that investigators at the Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, reported on February 7, 2018 (Lai et al., Sci. Transl. Med.10, eaan8735 (2018)) that in animal models Lixte’s protein phosphatase 2A (PP2A) inhibitors overcome resistance of chronic myelogenous leukemia (CML) cells to standard treatment.

 Dr. John S. Kovach, CEO of Lixte, said "The vast majority of CML cells are killed by drugs called tyrosine kinase inhibitors (TKI), the prototype of which is imatinib (Gleevec), considered the first truly targeted form of chemotherapy. Imatinib and subsequent variants were a great advance in turning CML from a fatal to a controllable illness. Almost without exception, however, from the onset of the disease some CML cells are resistant to TKI treatment so that continuous therapy is required and in some patients the number of TKI resistant cells accelerates out of control. The persistence and progression of CML despite TKI treatment is believed to arise from a niche of intrinsically resistant leukemia stem cells. The Terry Fox investigators found inhibition of PP2A with LB-100 or LB-102 preferentially sensitizes these resistant CML cells to killing by TKI compared to normal bone marrow stem cells. If these results can be replicated in the clinic, LB-100 and analogs may further improve the effectiveness of CML therapy.”

 About Lixte Biotechnology Holdings, Inc.

Lixte is a biotech company that identifies enzyme targets associated with serious common diseases and then designs novel compounds to attack those targets. Lixte's product pipeline encompasses two major categories of compounds at various stages of pre-clinical and clinical development that the Company believes have broad therapeutic potential not only for cancer but also for other debilitating and life-threatening diseases.

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Source: Lixte Biotechnology Holdings, Inc.