Published on January 7, 2009
EXHIBIT
16.1
AJ.
ROBBINS, P.C.
CERTIFIED
PUBLIC ACCOUNTANTS
216
SIXTEENTH STREET
SUITE
600
DENVER,
COLORADO 80202
January
6, 2009
United
States Securities and
Exchange
Commission
450 Fifth
Street, N.W.
Washington,
D.C. 20549
Re: Lixte
Biotechnology Holdings, Inc.
Dear
Sir/Madam:
We have
read Item 4.01 of the form 8-K Lixte Biotechnology Holdings, Inc., dated
December 17, 2008, as amended on January 6, 2009, regarding the recent change of
auditors. We agree with such statement made regarding our firm. We have no basis
to agree or disagree with other statements made under Item 4.01.
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Very
truly yours,
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AJ.
Robbins, PC
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by
/s/Richard
Fleischman
Richard Fleischman, CPA
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