Published on December 22, 2008
EXHIBIT
16.1
AJ.
ROBBINS, P.C.
CERTIFIED
PUBLIC ACCOUNTANTS
216
SIXTEENTH STREET
SUITE
600
DENVER,
COLORADO 80202
December
19, 2008
United
States Securities and
Exchange
Commission
450 Fifth
Street, N.W.
Washington,
D.C. 20549
Re: Lixte
Biotechnology Holdings, Inc.
Dear
Sir/Madam:
We have
read Item 4.01 of the form 8-K Lixte Biotechnology Holdings, Inc., dated
December 17, 2008 regarding the recent change of auditors. We agree with such
statement made regarding our firm. We have no basis to agree or disagree with
other statements made under Item 4.01.
Very truly yours,
AJ. Robbins, PC
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/s/Richard Fleischman
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Richard
Fleischman, CPA
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