Published on August 14, 2007
Exhibit
31
CERTIFICATIONS
I,
John
S. Kovach, Chief Executive Officer and Chief Financial Officer, certify
that:
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1.
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I
have reviewed this Quarterly Report on Form 10-QSB of Lixte Biotechnology
Holdings, Inc.;
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2.
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Based
on my knowledge, this report does not contain any untrue statement
of
material fact or omit to state a material fact necessary to make
the
statements made, in light of the circumstances under which such
statements
were made, not misleading with respect to the period covered by
this
report;
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3.
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Based
on my knowledge, the financial statements, and other financial
information
included in this report, fairly present in all material respects
the
financial condition, results of operations and cash flows of the
small
business issuer as of, and for, the periods presented in this
report;
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4.
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I
am responsible for establishing and maintaining disclosure controls
and
procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e))
and
internal control over financial reporting (as defined in Exchange
Act
Rules 13a-15(f) and 15d-15(f)) for the small business issuer and
have:
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a.
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designed
such disclosure controls and procedures, or caused such disclosure
controls and procedures to be designed under my supervision, to
ensure
that material information relating to the small business issuer,
including
its consolidated subsidiaries, is made known to me by others within
those
entities, particularly during the period in which this report is
being
prepared;
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b.
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omitted;
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c.
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evaluated
the effectiveness of the small business issuer’s disclosure controls and
procedures and presented in this report my conclusions about the
effectiveness of the disclosure controls and procedures, as of
the end of
the period covered by this report based on such evaluation;
and
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d.
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disclosed
in this report any change in the small business issuer’s internal control
over financial reporting that occurred during the small business
issuer’s
most recent fiscal quarter (the small business issuer’s fourth fiscal
quarter in the case of an annual report) that has materially affected,
or
is reasonably likely to materially affect, the small business issuer’s
internal control over financial reporting;
and
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5.
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I
have disclosed, based on my most recent evaluation of internal
control
over financial reporting, to the small business issuer’s auditors and the
audit committee of the small business issuer’s board of directors (or
persons performing the equivalent
functions):
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a.
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All
significant deficiencies and material weaknesses in the design or
operation of internal control over financial reporting which are
reasonably likely to adversely affect the small business issuer’s ability
to record, process, summarize and report financial information;
and
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b.
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Any
fraud, whether or not material, that involves management or other
employees who have a significant role in the small business issuer’s
internal control over financial
reporting.
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| Date: August 13, 2007 | By: | /s/ JOHN S. KOVACH |
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John
S. Kovach
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Chief
Executive Officer and Chief Financial Officer
(Principal
financial and accounting
officer)
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