Form: EFFECT

Notice of Effectiveness

April 10, 2025

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

Notice of Effectiveness

Effectiveness Date: April 10, 2025 5:00 P.M.
Form: S-1
CIK: 0001335105
Company Name: LIXTE BIOTECHNOLOGY HOLDINGS, INC.
File Number: 333-286385