Form: EFFECT

Notice of Effectiveness

August 21, 2023

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

Notice of Effectiveness

Effectiveness Date: August 21, 2023 4:00 P.M.
Form: S-3
CIK: 0001335105
Company Name: LIXTE BIOTECHNOLOGY HOLDINGS, INC.
File Number: 333-273932