Form: 3

Initial statement of beneficial ownership of securities

February 1, 2010

FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  SCHWARTZBERG DEBBIE
 2. Date of Event Requiring Statement (Month/Day/Year)
01/20/2010		 3. Issuer Name and Ticker or Trading Symbol
LIXTE BIOTECHNOLOGY HOLDINGS, INC. [LIXT.OB]
(Last)
(First)
(Middle)
269 SOUTH BEVERLY DRIVE, NO. 1315		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

BEVERLY HILLS, CA 90212		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 1,504,845
D
 
Common Stock 684,000
I
by the Julie Schwartzberg Trust (1)
Common Stock 650,000
I
by the David N. Sterling Trust (2)
Common Stock 994,700
I
by spouse

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Warrant 12/31/2009 12/31/2012 Common Stock 1,000,000 $ 0.5 D  
Warrant 12/31/2009 12/31/2012 Common Stock 1,000,000 $ 0.75 D  
Warrant 12/31/2009 12/31/2012 Common Stock 500,000 $ 0.5 I by spouse
Warrant 12/31/2009 12/31/2012 Common Stock 500,000 $ 0.75 I by spouse
Warrant 12/31/2009 12/31/2012 Common Stock 500,000 $ 0.5 I by Julie Schwartzberg Trust (1)
Warrant 12/31/2009 12/31/2012 Common Sstock 500,000 $ 0.75 I by Julie Schwartzberg Trust (1)
Warrant 12/31/2009 12/31/2012 Common Stock 500,000 $ 0.5 I by David N. Sterling Trust (2)
Warrant 12/31/2009 12/31/2012 Common Stock 500,000 $ 0.75 I by David N. Sterling Trust (2)
Option 09/12/2007 09/12/2011 Common Stock 500,000 $ 1 I by spouse
option 09/12/2008 09/12/2011 Common Stock 500,000 $ 1 I by spouse
Option 10/07/2009 09/12/2013 Common Stock 500,000 $ 1 I by spouse

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
SCHWARTZBERG DEBBIE
269 SOUTH BEVERLY DRIVE, NO. 1315
BEVERLY HILLS, CA 90212		     X    

Signatures

/s/ Debbie Schwartzberg 02/01/2010
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Ms. Schwartzberg is a co-trustee of the Julie Schwartzberg Trust in which she shares voting, disposition and investment control over the securities.
(2) Ms. Schwartzberg is a co-trustee of the David N. Sterling Trust in which she shares voting, disposition and investment control over the securities.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.